Type Two Diabetes (T2D)

Cell 150, 1223-1234, 2012

Domenico Accili at Columbia studying mouse Foxo1 gene discovered that pancreatic Islet β cells do not die in type-two diabetes (T2D) but revert back to endocrine progenitor cells that are unable to make insulin. This opens the possibility of treating T2D by turning these dormant cells back to normal. Once more an exciting contribution from genomics.

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Existentialism

There are more things in this World Horatio, than are dreamed of in your philosophies Shakespeare Definitions from Oxford Languages · Learn more: adjective relating to existence. "The climate crisis is an existential threat to the world." PHILOSOPHY concerned with existence, especially human existence as viewed in the theories of existentialism. "The existential dilemma is this: because we are free, we are also inherently responsible." LOGIC (of a proposition) affirming or implying the existence of a thing. the existential proposition that truth and reality are constructed fictions" Even physicists struggle with truth. Reality in the laws of physics repeatedly give way to new findings. The James Webb Telescope finds galaxies beyond the time and space of the established Universe. Anthropologists find evidence of civilizations earlier than documented history. What is truth? The use of the word existential as a syndrome for virtual truth begs the question o...

Domestic Labor

A smal incrament of domestic economic activity drives a large increase in the GDP. Vvelocity times money supply equals gross domestic product (GDP). The Velocity in single didgits when multiplied by money in the trillions has far greater effect than interest rates. For many decades, society overlooked and denounced Domestic labord. IRS reporting requirements, imcontax on the worker and social stigma discouraged if not eliminated this valuable segment of the labor force. Tax free, regulation free, domestic employment would add a significant boost to the overall economy, employ the unemployable, and provide shelter to the homeless, not a hundred percent, but to a significant degree. Think affordable houskeeping, cooking, and babysitting for the single mother working long hours.

Rick Atkinson

THE FATE OF THE DAY , just released, The war for America QUOTE George Washington. Our conflict is not likely to cease so soon as every good man would wish....Our cause is noble. it is the cause of mankind, and the danger to it springs from ourselves. March 31, 1779

Hughesair (Inflection Point)

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